منابع مشابه
High prevalence of testicular cancer in azoospermic men without spermatogenesis.
BACKGROUND An increased risk of testicular cancer in men with infertility and poor semen quality has been reported. Our aim was to investigate the prevalence of testicular nodules and cancer in azoospermic subjects with different spermatogenetic patterns. METHODS A total of 1443 consecutive infertile men were investigated, out of which 145 (10.0%) were found to be azoospermic. By using clinic...
متن کاملGPER Signaling in Spermatogenesis and Testicular Tumors
Estrogens play important roles in the regulation of testis development and spermatogenesis. Moreover, several evidences suggest that estrogen signaling can be involved in testicular tumorigenesis. The physiological effects of estrogen are mediated by the classical nuclear estrogen receptors ESR1 and 2, which regulate both genomic and rapid signaling events. In the recent years, a member of the ...
متن کاملMultiple effects on testicular signaling and spermatogenesis
In the past century, the drastic advancement in industrialization and technology and the growth in human population have driven a change to the environment to a scope that is unprecedented in human history. The production of large amounts of synthetic industrial and biomedical chemicals, as well as unwanted pollutants pose destructive consequences to our ecosystem and impose negative health eff...
متن کاملTesticular postgenomics: targeting the regulation of spermatogenesis.
Sperm are, arguably, the most differentiated cells produced within the body of any given species. This is owing to the fact that spermatogenesis is an intricate and highly specialized process evolved to suit the individual particularities of each sexual species. Despite a vast diversity in method, the aim of spermatogenesis is always the same, the idealized transmission of genetic patrimony. To...
متن کاملFetal Cyclophosphamide Exposure Induces Testicular Cancer and Reduced Spermatogenesis and Ovarian Follicle Numbers in Mice
Exposure to radiation during fetal development induces testicular germ cell tumors (TGCT) and reduces spermatogenesis in mice. However, whether DNA damaging chemotherapeutic agents elicit these effects in mice remains unclear. Among such agents, cyclophosphamide (CP) is currently used to treat breast cancer in pregnant women, and the effects of fetal exposure to this drug manifested in the offs...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 1997
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/12.4.755